International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Most Trusted Research Journal Since Year 2012

ISSN: 2319-7064



Research Paper | Biology Science | India | Volume 4 Issue 4, April 2015

Risk Assessment of Lead Induced Toxicity Profiling from Toxicogenomics Data of Human Cell Lines

Arpitha B M

Heavy metal toxicity is a health menace and is posing a significant risk because of adulteration of drinking water and often associated with folk lore therapies. Lead induced toxicity poses considerable impact on the developing brains of fetuses and young children, including pregnant women. Gene expression profiling studies has made advancement in identifying key regulatory genes responsible for complex diseases. In this study, an effort has been made to assess the risk of lead induced toxicity by conducting toxico-genomics profile analysis that involved identification, characterization and mapping of significantly expressed genes to lead induced diseases. The data source used in this study was derived from Affymetrix cDNA Microarray based experiment on Lead acetate induced Peripheral blood mononuclear cells. The data was retrieved from public repositories, cleaned and further processed before statistical treatments. The results demonstrated significant expression of Metallothionein family of genes in lead acetate induced cell-lines. Further, annotation of these genes gave insights into the complex relationship of the genes with clinical outcomes observed during lead toxicity. Mapping of these genes by means of GENEMANIA produced a scale-free gene expression network. The study reveals an intricate relationships of heavy metal induced genes and their respective disease association in a scale free network.

Keywords: Metallothionein, Heavy metal toxicity, Biological Networks, Gene expression profiling, Lead acetate

Edition: Volume 4 Issue 4, April 2015

Pages: 1288 - 1291

Share this Article

How to Cite this Article?

Arpitha B M, "Risk Assessment of Lead Induced Toxicity Profiling from Toxicogenomics Data of Human Cell Lines", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=8041501, Volume 4 Issue 4, April 2015, 1288 - 1291

31 PDF Views | 31 PDF Downloads

Download Article PDF

Similar Articles with Keyword 'Metallothionein'

Research Paper, Biology Science, India, Volume 4 Issue 4, April 2015

Pages: 1288 - 1291

Risk Assessment of Lead Induced Toxicity Profiling from Toxicogenomics Data of Human Cell Lines

Arpitha B M

Share this Article

Research Paper, Biology Science, India, Volume 7 Issue 8, August 2018

Pages: 1315 - 1318

Combined Effect of Heavy Metals on Longevity of Drosophila Melanogaster

V. Shakunthala, Shalini H.K

Share this Article

Similar Articles with Keyword 'Lead acetate'

Research Paper, Biology Science, India, Volume 4 Issue 4, April 2015

Pages: 1288 - 1291

Risk Assessment of Lead Induced Toxicity Profiling from Toxicogenomics Data of Human Cell Lines

Arpitha B M

Share this Article

Research Paper, Biology Science, India, Volume 7 Issue 8, August 2018

Pages: 1315 - 1318

Combined Effect of Heavy Metals on Longevity of Drosophila Melanogaster

V. Shakunthala, Shalini H.K

Share this Article

Research Paper, Biology Science, Libya, Volume 4 Issue 2, February 2015

Pages: 2053 - 2063

Protective Effects of Sesame Oil against Lead Acetate Induced Haemato-Biochemical Toxicity in Albino Mice

Azab El-Sayed Azab, El-Dakhly.A.T, Qutaiba K. Alrawi, Mohamed O. Albasha

Share this Article



Top