Formulation and Evaluation of Simvastatin Solid Dispersion Tablets
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064

Research Paper | Medicine Science | India | Volume 3 Issue 8, August 2014

Formulation and Evaluation of Simvastatin Solid Dispersion Tablets

Suraj Ashok Bhagat, Aditya Vikas Sakhare

The purpose of the study is to improve the dissolution & stabilization of simvastatin, a poorly water soluble drug by solid dispersion. Simvastatin belongs to BCS class 2 having low solubility & therefore low oral bioavailability (5 %) 3.the solid dispersions is prepared by kneading method us using carriers at different drug carriers ratio (pvp-k30). The characterization of solid state properties of pure simvastatin is done by using FTIR. The formulation of simvastatin is done by direct compression method. The evaluation of formulated simvastatin is done by using physiochemical parameters such as hardness, friability, weight variation, uniformity of drug content &In vitro dissolution time.

Keywords: FORMULATION, EVALUATION, SIMVASTATIN, DISPERSION

Edition: Volume 3 Issue 8, August 2014

Pages: 1050 - 1057

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Suraj Ashok Bhagat, Aditya Vikas Sakhare, "Formulation and Evaluation of Simvastatin Solid Dispersion Tablets", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=2015569, Volume 3 Issue 8, August 2014, 1050 - 1057

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