International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064




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Research Paper | Biochemistry Science | India | Volume 3 Issue 8, August 2014


Study on Significance of C- Reactive Protein Estimation in Early Diagnosis of Neonatal Septicemia

Dr Yatish Goswami | Dr Prashant Jadav | Dr Bhumika Rathod


Abstract: BACKGROUND: Septicemia is major problem in neonates. Clinical criteria alone could not establish the diagnosis of neonatal septicemia. However, empirical treatment should not be delayed because of the high mortality. C- reactive protein, an acute phase protein, increases in inflammatory disorders and tissue injury. OBJECTIVES: 1. To evaluate the diagnostic accuracy of CRP in neonatal sepsis METHOD: A prospective study included newborn infants, aged < 30 days and diagnosed with septicemia, who were admitted in neonatal intensive care unit at Sir T Hospital, Bhavnagar during 8- month period. This study included 200 cases in which 100 were culture proven septicemia and 100 normal newborn. Investigations for infection included CBC, blood culture and urine culture. RESULTS: As per present study, sensitivity of Serum CRP is 91 % and specificity being 94 % with NPV of 91.2 % suggesting its beneficial role in diagnosing sepsis. As per the study, Serum CRP was positive in 91 % of culture proven sepsis and negative in 9 % of cases. p value of the test applied for the statistical significance is < 0.05 which implies that the result is statistically significant for CRP. CONCLUSION: CRP is most commonly used laboratory test for neonatal bacterial infection and despite the continuing emergence of new infection markers it still plays a central role in the diagnosis of early onset neonatal septicemia.


Keywords: C-reactive protein CRP, Neonatal septicemia


Edition: Volume 3 Issue 8, August 2014,


Pages: 388 - 390


How to Cite this Article?

Dr Yatish Goswami, Dr Prashant Jadav, Dr Bhumika Rathod, "Study on Significance of C- Reactive Protein Estimation in Early Diagnosis of Neonatal Septicemia", International Journal of Science and Research (IJSR), Volume 3 Issue 8, August 2014, pp. 388-390, https://www.ijsr.net/get_abstract.php?paper_id=2015132

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