International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Most Trusted Research Journal Since Year 2012

ISSN: 2319-7064



Research Paper | Biology Science | India | Volume 3 Issue 6, June 2014

Comparative Evaluation of Immune Protective Effect of Melatonin and Boerhaavia diffusa in Lymphoid Tissues of Park?s Strain Mice against Antibiotic Induced Oxidative Stress

Somenath Ghosh, Shweta Sharma, Abhinav Joshi, Chandana Haldar

Boerhaavia diffusa; a native plant of India; is an antioxidant. Aims were to compare; physiological efficacy of root and stem extracts of B. diffusa either alone or in combination with melatonin on improvement of immune and antioxidant status of mice under normal or antibiotic induced stress. Parks strain mice were grouped into control (Con) ; melatonin (Mel) ; ethanolic root (BRE) and stem (BSE) extract treated alone and in combination with melatonin (BRE+Mel and BSE+Mel). Further; mice were grouped into control (Con) ; ampicillin treated (AMP) ; and BRE; BSE and Mel pre-treated groups receiving AMP (AMP+BSE; AMP+BRE; AMP+Mel). Blood and spleens of all the groups were collected and processed for Total Leukocyte Count (TLC) ; % Stimulation Ratio ( %SR) of splenocytes; estimations of Total Anti-oxidant Status (TAS) ; TBARS; Super Oxide Dismutase (SOD) and apoptosis analysis (Et-Br Assay). Significant increase in TLC; % SR of splenocytes; TAS level; SOD and significant decrease in apoptotic index of splenocytes and TBARS level in BSE+Mel; BRE+Mel; AMP+Mel than Con; Mel; BRE; BSE; AMP; AMP+BSE and AMP+BRE treatments were noted. Conclusively; melatonin in combination with root and stem extracts of B. diffusa improved immune and antioxidant status. Melatonin pre-treatment alone ameliorates ampicillin induced immune compromised condition and oxidative stress.

Keywords: Antibiotic, Antioxidant, Boerhaavia, Melatonin, Mice

Edition: Volume 3 Issue 6, June 2014

Pages: 1111 - 1120


How to Cite this Article?

Somenath Ghosh, Shweta Sharma, Abhinav Joshi, Chandana Haldar, "Comparative Evaluation of Immune Protective Effect of Melatonin and Boerhaavia diffusa in Lymphoid Tissues of Park?s Strain Mice against Antibiotic Induced Oxidative Stress", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=2014391, Volume 3 Issue 6, June 2014, 1111 - 1120

24 PDF Views | 21 PDF Downloads

Download Article PDF



Similar Articles with Keyword 'Antibiotic'

Review Papers, Biology Science, Azerbaijan, Volume 5 Issue 4, April 2016

Pages: 2276 - 2279

Modern Conceptions about Antibiotic Levorin A and its Derivatives Action in Cell and Bilayer Lipid Membranes

Dr. Samedova Arifa Ali Hasan, Dr. Sultanova Gulnar Hadjibek

Share this article

Research Paper, Biology Science, India, Volume 3 Issue 7, July 2014

Pages: 488 - 489

Antibiotic Sensitivity Test on E. coli Isolates from Different Sources

Sumona Chakrabortty, Dr. Rachana Choudhary, Dr. Sonia Bajaj

Share this article

Research Paper, Biology Science, India, Volume 4 Issue 4, April 2015

Pages: 1950 - 1954

An Integrative Approach for In Silico Study on Treating Molluscum Contagiosum with Snail Slime

Deepak Tom Jose, Caroline Nirmala. R

Share this article

Research Paper, Biology Science, India, Volume 3 Issue 6, June 2014

Pages: 1111 - 1120

Comparative Evaluation of Immune Protective Effect of Melatonin and Boerhaavia diffusa in Lymphoid Tissues of Park?s Strain Mice against Antibiotic Induced Oxidative Stress

Somenath Ghosh, Shweta Sharma, Abhinav Joshi, Chandana Haldar

Share this article

Research Paper, Biology Science, India, Volume 3 Issue 8, August 2014

Pages: 1972 - 1974

Inhibition of Antibiofilm Mediated Virulence Factors Production in Urinary Pathogen Serratia marcescens by Vitex Trifolia

R. Nancy Immaculate Mary, N. Banu

Share this article



Similar Articles with Keyword 'Antioxidant'

Research Paper, Biology Science, India, Volume 4 Issue 2, February 2015

Pages: 1304 - 1306

Effect of Cd?? On Catalase Activity on Air Breathing Fresh Water Teleost Fish Heteropneustes fossilis (Bloch)

Anupama Shrivastava, Sabiha Naz

Share this article

Review Papers, Biology Science, India, Volume 5 Issue 3, March 2016

Pages: 1984 - 1987

Phytonutrient Rich Medicinal Plant ?Centella Asiatica? As Brain Enhancing Potential-A Reviews

Anjusana Khundrakpam, Dr. PL Sridevi Sivakami

Share this article

Research Paper, Biology Science, India, Volume 4 Issue 3, March 2015

Pages: 2230 - 2237

Attenuation of NFkB Activation Augments Alveolar Transport Proteins Expression and Activity under Hypoxia

Titto Mathew, Sarada SKS

Share this article

Research Paper, Biology Science, India, Volume 3 Issue 7, July 2014

Pages: 661 - 663

Genetic Transformation & Gus Gene Expression in Piper longum

Sudipta Banerjee, M. A. Mallick

Share this article

Research Paper, Biology Science, India, Volume 3 Issue 7, July 2014

Pages: 1906 - 1909

The Improvement of Pleuorotus Species Cultivated On Soybean Straw Bed Supplemented with Flax Seed Meal

Anuradha Jape, Devyani Salunke, Supriya Dighe, Abhay Harsulkar

Share this article



Similar Articles with Keyword 'Melatonin'

Research Paper, Biology Science, India, Volume 3 Issue 6, June 2014

Pages: 1111 - 1120

Comparative Evaluation of Immune Protective Effect of Melatonin and Boerhaavia diffusa in Lymphoid Tissues of Park?s Strain Mice against Antibiotic Induced Oxidative Stress

Somenath Ghosh, Shweta Sharma, Abhinav Joshi, Chandana Haldar

Share this article

Research Paper, Biology Science, Saudi Arabia, Volume 6 Issue 2, February 2017

Pages: 1733 - 1738

The Effect of the Melatoninhormone on the Performance of the Ovaries in Naimi Sheep when Exposed to Different Periods of Light

Maen Idell, Fathi Elhag

Share this article



Similar Articles with Keyword 'Mice'

Research Paper, Biology Science, Malaysia, Volume 7 Issue 9, September 2018

Pages: 919 - 925

Evaluation of Sub-Acute Toxicity of Ficuscarica Spray-Dried Leaf Extract in Sprague Dawley Mice

Zuraida Ab Rahman, Shazwan Abd Shukor, Hartinee Abbas, Chandradevan A/L Machap, Mohd Suhaimi Bin Alias, Razali Mirad, Ayu Nazreena Othman

Share this article

Research Paper, Biology Science, India, Volume 3 Issue 6, June 2014

Pages: 1111 - 1120

Comparative Evaluation of Immune Protective Effect of Melatonin and Boerhaavia diffusa in Lymphoid Tissues of Park?s Strain Mice against Antibiotic Induced Oxidative Stress

Somenath Ghosh, Shweta Sharma, Abhinav Joshi, Chandana Haldar

Share this article

Research Paper, Biology Science, Libya, Volume 4 Issue 2, February 2015

Pages: 2053 - 2063

Protective Effects of Sesame Oil against Lead Acetate Induced Haemato-Biochemical Toxicity in Albino Mice

Azab El-Sayed Azab, El-Dakhly.A.T, Qutaiba K. Alrawi, Mohamed O. Albasha

Share this article

Research Paper, Biology Science, India, Volume 4 Issue 11, November 2015

Pages: 1544 - 1551

Analysis of Monolaurin, Beta- Carotene, Weakened Beta-Carotene and their Antagonistic Properties with HIV: An Exploratory Study

Paul Inbaraj.

Share this article

Research Paper, Biology Science, Egypt, Volume 5 Issue 12, December 2016

Pages: 1548 - 1555

Haematological Parameters and Cellular Immune Response Associated with Administration of Polyvalent Schistosomamansoni Vaccine in Mice

Abdel-Hakeem, S.S. Abdel-Zaher, M. Abed G. H.

Share this article
Top