p-Aminobenzoic Acid as a New Reagent in Spectrophotometric Determination of Salbutamol Sulphate Via Oxidative Coupling Reaction
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
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ISSN: 2319-7064

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Research Paper | Chemistry | Iraq | Volume 7 Issue 8, August 2018

p-Aminobenzoic Acid as a New Reagent in Spectrophotometric Determination of Salbutamol Sulphate Via Oxidative Coupling Reaction

Nabeel S. Othman Ali M. Asaad

A simple spectrophotmetic method for the determination of salbutamol sulphate (SBS) in aqueous solution has been suggested. The method is based on the oxidative coupling reaction of SBS with p-aminobenzoic acid (PABA) in an alkaline medium (pH=11.96) in presence of N-chlorosuccinimide (NCS) as oxidizing agent to produce an intense blue colored, water soluble and stable product, which showed maximum absorption at 622 nm. Beers law is obeyed over the range2.0 - 25.0 g.ml-1 of SBS and limit of detection (LOD) of 0.460 g.ml-1, limit of quantitation (LOQ) of 1.536 g.ml-1, a molar absorptivity of 1.828104 l.mol-1.cm-1. and Sandells sensitivity index of 0.0315 g.cm-2. The method has been successfully applied to the determination of SBS in pharmaceutical preparations.

Keywords: spectrophotometry, salbutamol sulphate, p-aminobenzoic acid, oxidative coupling reaction, N-chlorosuccinimide

Edition: Volume 7 Issue 8, August 2018

Pages: 39 - 43

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Nabeel S. Othman Ali M. Asaad, "p-Aminobenzoic Acid as a New Reagent in Spectrophotometric Determination of Salbutamol Sulphate Via Oxidative Coupling Reaction", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=13061801, Volume 7 Issue 8, August 2018, 39 - 43

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