International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064




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Research Paper | Biochemistry | India | Volume 2 Issue 7, July 2013


Role of Grape Seed Proanthocyanidins in the Suppression of High Calorie Diet-Induced Hepatic Injury and Apoptosis

Baskaran Yogalakshmi | Carani Venkatraman Anuradha


Abstract: Hepatocyte oxidative stress and apoptosis are considered to be the key components in the pathogenesis of nonalcoholic steatohepatitis. In this study we investigated the effect of grape seed proanthocyanidins (GSP) and metformin (MET), alone and in combination, on high fructose/fat diet (HFFD) induced steatohepatitis, with focus on oxidative stress and apoptosis markers. NASH was induced in male albino Wistar rats by feeding HFFD for 45 days. Either GSP (100 mg/kg b. w), MET (50 mg/kg b. w) or both were administered as therapeutic options. HFFD-feeding caused increase in lipid peroxides, protein carbonyls, proapoptotic proteins, (bax, caspases 3 and 9) and decline in anti-apoptotic protein (bcl2). Further, growth and DNA damage (GADD) 45, an NF-B regulated anti-apoptotic factor, was also reduced in HFFD-fed rats. These changes were reversed more effectively by GSP administration than by MET. Combined administration of GSP and MET showed synergistic effect in improving cell survival and hence could be considered for controlling HFFD-induced hepatocyte apoptosis.


Keywords: Grape seed proanthocyanidins, hepatic injury, oxidative stress, apoptosis


Edition: Volume 2 Issue 7, July 2013,


Pages: 406 - 411

Role of Grape Seed Proanthocyanidins in the Suppression of High Calorie Diet-Induced Hepatic Injury and Apoptosis


How to Cite this Article?

Baskaran Yogalakshmi, Carani Venkatraman Anuradha, "Role of Grape Seed Proanthocyanidins in the Suppression of High Calorie Diet-Induced Hepatic Injury and Apoptosis", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=1201373, Volume 2 Issue 7, July 2013, 406 - 411, #ijsrnet

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