Acute Lymphoblastic Leukemia - An Overview
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064

Research Paper | Oncology Science | India | Volume 3 Issue 1, January 2014

Acute Lymphoblastic Leukemia - An Overview

Dalia Tewary, Jayita Dey Mondal, Samadrita Mukherjee Sardar

Acute lymphoblastic leukemia (ALL) is a malignant disorder resulting from the clonal proliferation of lymphoid precursors with arrested maturation. Specific chromosomal translocations in ALL include mainly, the classical t (8; 14) in B-cell ALL, t (4; 11) in infant leukemia and t (9; 22) translocation (that forms the Philadelphia chromosome). Genome-wide profiling using microarrays, candidate gene, and second generation sequencing have provided a number of key insights into the genetic basis of ALL. Treatment for acute lymphoblastic leukemia typically consists of a remission-induction phase, an intensification (or consolidation) phase, and continuation therapy to eliminate residual disease. Allogeneic haemopoietic stem-cell transplantation is the most intensive form of treatment for acute lymphoblastic leukemia as it clearly benefits several subgroups of patients with high-risk acute lymphoblastic leukemia. Although relatively homogeneous at the morphologic and immunophenotypic level, ALL encompasses a family of extremely heterogeneous disorders when examined at the genetic level. More insights are needed to further improve the treatment outcome of patients with ALL.

Keywords: Acute lymphoblastic leukemia ALL, Philadelphia chromosome, translocation, B-cell ALL, T-cell ALL

Edition: Volume 3 Issue 1, January 2014

Pages: 110 - 114

Share this Article

How to Cite this Article?

Dalia Tewary, Jayita Dey Mondal, Samadrita Mukherjee Sardar, "Acute Lymphoblastic Leukemia - An Overview", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=02013752, Volume 3 Issue 1, January 2014, 110 - 114

128 PDF Views | 74 PDF Downloads

Download Article PDF



Similar Articles with Keyword 'Philadelphia chromosome'

Research Paper, Oncology Science, India, Volume 3 Issue 1, January 2014

Pages: 110 - 114

Acute Lymphoblastic Leukemia - An Overview

Dalia Tewary, Jayita Dey Mondal, Samadrita Mukherjee Sardar

Share this Article

Research Paper, Oncology Science, India, Volume 3 Issue 1, January 2014

Pages: 129 - 132

Chronic Myeloid Leukemia ? An Overview

Jayita Dey Mondal, Dalia Tewary, Samadrita Mukherjee Sardar

Share this Article

Similar Articles with Keyword 'translocation'

Research Paper, Oncology Science, India, Volume 3 Issue 1, January 2014

Pages: 110 - 114

Acute Lymphoblastic Leukemia - An Overview

Dalia Tewary, Jayita Dey Mondal, Samadrita Mukherjee Sardar

Share this Article

Research Paper, Oncology Science, India, Volume 3 Issue 1, January 2014

Pages: 129 - 132

Chronic Myeloid Leukemia ? An Overview

Jayita Dey Mondal, Dalia Tewary, Samadrita Mukherjee Sardar

Share this Article
Top