Research Paper | Chemistry | India | Volume 3 Issue 1, January 2014
Sensitive Spectrophotometric Methods for the Determination of Nicardipine in Pharamaceuticals Using Bromothymol Blue and Methyl
Y. Suneetha, N. V. S. Naidu
Simple, sensitive and rapid spectrophotometric methods are developed for the determination of Nicardipine in pharmaceutical formulations. Method A is based on the extractive spectrophotometry and the final color developed is due to ion association complex formation with Bromothymol blue (BTB) at PH 3.7 resulting in the formation of a yellow color solution that exhibited maximum absorption at wavelength 380nm. Method B is based on the yellow color developed which is due to ion association complex between methyl orange (MO) at PH 3.7 and nicardipine that exhibited maximum absorption at a wave length of 430nm. Both ion association complexes are extracted into chloroform and Beers law is obeyed over the concentration ranges 1.0-10.0 gml-1 and 2.0-10.0 gml-1 for methods A and B respectively. Both the methods have been successfully applied for the assay of the drug in pharmaceutical formulations. There is No interference was observed from common pharmaceutical adjuvants. The reliability and the performance of the proposed methods are established by point and interval hypothesis tests and through recovery studies.
Keywords: Nicardipine, Bromothymol blue BTB, Methylorange MO, Spectrophotometer, Bulk drugs and tablet formulations
Edition: Volume 3 Issue 1, January 2014
Pages: 25 - 28
How to Cite this Article?
Y. Suneetha, N. V. S. Naidu, "Sensitive Spectrophotometric Methods for the Determination of Nicardipine in Pharamaceuticals Using Bromothymol Blue and Methyl", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=02013443, Volume 3 Issue 1, January 2014, 25 - 28
44 PDF Views | 40 PDF Downloads
Similar Articles with Keyword 'Spectrophotometer'
A Simple Rapid Spectrophotometric Investigation of Diquat and its Applications
S. Pradhan, M. K. Rai, J. K Rai
Determination of Tetracycline Hydrochloride in Pharmaceutical Preparations by Molecular Absorption and Indirect Flame Atomic Absorption Spectrophotometry Using Platinum (IV) as Complexing Metal
Fatima Ali, Rana Adel Kamoon
A Comparative Study of Concentration of Caffeine and Benzoic Acid in Various Soft Drink Samples
Reena Gami, Geetha Sarasan
Determination of Hydroquinone in Some Pharmaceutical and Cosmetic Preparations by Spectrophotometric Method
Hawaa S. Elferjani, Najw H. S. Ahmida, Aziza Ahmida
Effect of Solvents on the Production of N-Acetyl Glucosamine as a Result of Enzymatic Hydrolysis of Chitin from Shrimp Shell Waste
Nuniek Herdyastuti, Sari Edi Cahyaningrum