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Case Studies | Pathology | India | Volume 13 Issue 10, October 2024 | Rating: 5 / 10
Leydig Cell Tumor Presented as Retroperitoneal Mass: A Case Report
Dr. Shruthi Surendran, Dr Kalaranjini K V, Dr Vivek George
Abstract: Background: Leydig cell tumour is a rare tumour of the male testicular interstitium. Testicular Leydig cell tumours can occur at any age but they are common in prepubertal boys and in men aged 30 to 60 years. Leydig cell tumours are always benign in children, whereas in adults they are malignant in 10% of cases. The etiology of LCTs is not completely understood and appears to be multifactorial. In this case, the risk factor which can be attributed to LCT is cryptorchidism. Case details: A 60 year old male came with complaints of recurrent lower abdominal pain. On evaluation, he was diagnosed as acute appendicitis with mucocele formation and an incidental retroperitoneal mass. He underwent exploratory laparotomy and excision of the retroperitoneal mass along with appendicectomy. Histopathology: The tumour had a nodular smooth surface with lobules of pale brown areas on cut section. Microscopically a circumscribed neoplasm arranged in solid pattern and cells with abundant granular cytoplasm, round nuclei was seen. There was also characteristic Reinke crystals, which was suggestive of a Leydig cell tumor. Conclusion: Undescended testes not operated early in life are seriously damaged and is a major risk factor for the development of LCT. Hence proper workup with hormonal assays, cross - sectional imaging and testicular biopsies are recommended. Sugery is the gold standard treatment option for LCT along with adjuvant therapies in high risk cases.
Keywords: Leydig cell tumor, Cryptorchidism, Retroperitoneal mass, Sex cord - stromal tumors
Edition: Volume 13 Issue 10, October 2024,
Pages: 934 - 938