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Review Papers | Pharmacy | India | Volume 12 Issue 4, April 2023 | Rating: 4.5 / 10
Anti Cancer Activity of Naturally Occurring Heterocyclic Compound
Shafia Sultana, Pilli Archana, Dr. M. Vijaya Bhargavi
Abstract: Indole compounds present in cruciferous vegetables have powerful anti-cancer capabilities. Indole-3-carbinol (I3C) and its dimeric form, 3, 3'-diindolylmethane (DIM), have been shown to block a number of cellular signaling pathways, including the PI3K/Akt/mTOR signaling pathway. These chemicals can block angiogenesis, overcome drug resistance, invasion, and change the phenotype of the epithelial-to-mesenchymal transition (EMT). It is becoming known that the PI3K/Akt/mTOR and NF-?b signaling pathways play an important role in EMT and control novel miRNAs. It has been examined how parental I3C and DIM, as well as their analogues and derivatives, regulate PI3K/Akt/mTOR/NF-B signaling.
Keywords: indole-3-carbinol, epithelial-to-mesenchymal transition, angiogenesis, cruciferous vegetables
Edition: Volume 12 Issue 4, April 2023,
Pages: 195 - 200