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Estrogen Receptors Expression in Lung Cancer and Breast Cancer

Ni Luh Gede Yoni Komalasari

Abstract: Lung cancer in women has been increased recently and some research found that it was not related to smoking habit. Increasing lung cancer risk in women with early onset of menopause and hormonal contraception using more than five years. Those indicated a connection of female hormon to the development of lung cancer. Estrogen is one of steroid hormon classes related to reproductive organs in female. Effect of estradiol is mediated by ER? and ER?. Both ER encoded by different gene, expressed to the same or different tissues in variated levels. Expression of ER? was mostly observed in breast cancer cells, while ER? commonly found in normal breast. The absence of ER? in knock out mice showed abnormality in lungs structure development and hypoxia. ERs expression was higher in NSCLC than normal lung tissues. ER expression highly connected with tumor differentiation. ER? with strong full length expression in cytoplasm and nucleus. As ER probably indicate prognosis of breast cancer, in lung cancer overexpression of ER? leads to poor prognosis in postmenopausal women and also agresive tumor. Furthermore the expression of ER?, ER? along with EGFR mutation possibly as biomarker and prognostic markers for lung cancer as well as breast cancer.

Keywords: estrogen receptor ?, estrogen receptor ?, lung cancer, breast cancer

Country: Indonesia, Subject Area: Medical Science

Pages: 1420 - 1422

Edition: Volume 8 Issue 7, July 2019

How to Cite this Article?

Ni Luh Gede Yoni Komalasari, "Estrogen Receptors Expression in Lung Cancer and Breast Cancer", International Journal of Science and Research (IJSR), https://www.ijsr.net/archive/v8i7/show_abstract.php?id=ART20199898, Volume 8 Issue 7, July 2019, 1420 - 1422

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