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Antioxidant and Anticancer Potential Test of Alikokop (Dischidia nythesiana) Leaf Methanol Extract

Ira Risye Manggribeth, Dingse Pandiangan, Parluhutan Siahaan

Abstract: This study aimed to determine the antioxidant and anticancer activity of methanol extract of Alikokop leaves (Dischidia nythesiana). The extraction method used is maceration extraction using methanol solvent. The antioxidant activity test was carried out using the DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical deterrent method and the anticancer activity assay was carried out using the MTT (Microculture Tetrazolium) method using P-388 cancer cells. From this study, the antioxidant test results showed that the methanol extract of Alikokop leaves had antioxidant activity with moderate concentration, with IC50 of 67.136 μg / mL, and the results of anticancer tests showed that methanol extract of Alikokop leaves had anticancer activity on leukemia cells P388 with concentration inhibition values medium, with IC50 of 24.88 μg / mL. The methanol extract of Alikokop leaves has the potential as an antioxidant and anticancer leukemia.

Keywords: antioxidant, anticancer, alikokop, methanol exstract, Dischidia nythesiana.

Country: Indonesia, Subject Area: Biological Sciences

Pages: 1134 - 1140

Edition: Volume 8 Issue 7, July 2019

How to Cite this Article?

Ira Risye Manggribeth, Dingse Pandiangan, Parluhutan Siahaan, "Antioxidant and Anticancer Potential Test of Alikokop (Dischidia nythesiana) Leaf Methanol Extract", International Journal of Science and Research (IJSR), https://www.ijsr.net/archive/v8i7/show_abstract.php?id=ART20199796, Volume 8 Issue 7, July 2019, 1134 - 1140

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