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Prevalence of Thyroid Dysfunction and Thyroid Autoimmunity in Patients with Type 1 Diabetes Mellitus attending Tertiary Care Hospital in Madurai, South India

Sridhar Subbiah, Vasanthiy Natarajan, Sangumani Jeyaraman

Abstract: Objectives: To assess the prevalence of thyroid dysfunction and antithyroid peroxidase (Anti ?TPO) positivity in patients with type 1 diabetes mellitus attending tertiary care centre in Madurai. Research Design & Methods: This was a cross sectional observational study among subjects with type 1 Diabetes mellitus attending Department of Endocrinology, Madurai Medical College, Madurai. Thyroid function tests (TFT) and antithyroid peroxidase (Anti ?TPO) were measured using the electro chemiluminiscence method. Results: A total of 177 patients (M: F, 92:85) were recruited and mean age was 11.58 ? 3.65 years (Range 2-18 years). Mean age at diagnosis and mean duration of diabetes mellitus was 9.5 ? 3.64 and 3.56 ? 3.1 years respectively. The prevalence of antithyroid peroxidase (Anti ?TPO) positivity was 29.9 % and the prevalence of overt, subclinical hypothyroidism and Graves? disease were 14.6%, 5.6% and 1.1% respectively. Significantly higher proportion of female has autoimmune positivity than males (71.7% vs 28.3%, respectively, P =0.005). Conclusion: Our study demonstrated that autoimmune hypothyroidism is highly prevalent among patients with type 1 diabetes mellitus. Screening for hypothyroidism and thyroid autoimmunity should be undertaken in all Type 1 Diabetes mellitus at diagnosis and periodic intervals.

Keywords: Thyroid autoimmune prevalence ? Type 1 diabetes ? Thyroid dysfunction ? Anti-thyroid peroxidase antibody

Country: India, Subject Area: Diabetology

Pages: 1321 - 1323

Edition: Volume 8 Issue 5, May 2019

How to Cite this Article?

Sridhar Subbiah, Vasanthiy Natarajan, Sangumani Jeyaraman, "Prevalence of Thyroid Dysfunction and Thyroid Autoimmunity in Patients with Type 1 Diabetes Mellitus attending Tertiary Care Hospital in Madurai, South India", International Journal of Science and Research (IJSR), https://www.ijsr.net/archive/v8i5/show_abstract.php?id=ART20198038, Volume 8 Issue 5, May 2019, 1321 - 1323

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