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Comparison of Two Different Doses of Dexmedetomidine in Decreasing the Extubation Response

Roshni Sebastian, Harshavardhan K

Abstract: ABSTRACT BACKGROUND : Laryngoscopy , intubation and extubation is associated with sympathetic stimulation which results in hypertension and tachycardia. Drugs modulating the sympathetic response can be used during extubation to decrease the sympathetic response AIM : To compare of two different doses of dexmedetomidine in decreasing the sympathetic response.. METHOD :A hospital based Prospective, randomized, double blind study where a total of 66 patients undergoing surgery under general Anaesthesia in our hospital were randomly divided into 2 groups: Group-D1: Dexmedetomidine (0.25mcg/kg) group ? 33 patients; Group-D2: Dexmedetomidine (0.5mcg/kg) group ? 33 patients. The hemodynamic parameters, airway reflexes were assessed in different intervals of time and compared. RESULT: heart rate and systolic and diastolic blood pressure were significantly lower in D2 group (0.5 ?g/kg) as compared to D1 group (0.2 ?g/kg ) .Smooth extubation was reported in 93.9% cases of D2 group as compared to 81.8% in D1 group. Rough experience was seen in 18.2% cases of D1 group as compared to 6.1% in D2 group (p-0.25). Mean time for extubation was significantly lower in D2 group (136.7 vs 224.5 sec; p

Keywords: KEYWORDS: extubation , dexmedetomidine , sympathetic response.

Country: India, Subject Area: Medical Science

Pages: 380 - 383

Edition: Volume 8 Issue 3, March 2019

How to Cite this Article?

Roshni Sebastian, Harshavardhan K, "Comparison of Two Different Doses of Dexmedetomidine in Decreasing the Extubation Response", International Journal of Science and Research (IJSR), https://www.ijsr.net/archive/v8i3/show_abstract.php?id=ART20193036, Volume 8 Issue 3, March 2019, 380 - 383

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